Public Health, Versorgungsforschung und HTA








The aim of the PREMIO COLLAB project is to prolong overall survival and to improve the quality of life for patients with metastatic breast cancer by providing refined guidance for the management of treatment response monitoring. Based on a pragmatic multicenter randomized clinical trial (RCT), the intervention of FDG-PET/CT-based monitoring will be compared with conventional CT as state-of-the-art. The objectives of the project are to analyze the impact of the intervention on overall survival and quality of life in patients with metastatic breast cancer and include cost-effectiveness and cost-utility analyses in order to directly inform HTA agencies and health policymakers.

The consortium of PREMIO COLLAB is led by Prof. Malene Grubbe Hildebrandt from the Department of Nuclear Medicine at the Odense University Hospital and consists of the following 13 partners in 7 European countries:

  1. Region of Southern Denmark, Odense University Hospital and Lillebaelt Hospital, Denmark
  2. Capital Region of Denmark, Rigshospitalet and Herlev Hospital, Denmark
  3. North Denmark Region, Aalborg University Hospital, Denmark
  4. Central Denmark Region, Aarhus University Hospital, Denmark
  5. University Hospital rechts der Isar, Munich, Germany
  6. Sant’Orsola-Malpighi Polyclinic, Bologna, Italy
  7. Humanitas Research Hospital, Italy
  8. Geneva University Hospital, Switzerland
  9. University of Southern Denmark, Denmark
  10. University of Bologna, Italy
  11. UMIT TIROL - University for Health Sciences and Technology, Austria
  12. University of Strathclyde, Glasgow, Scotland
  13. Research Consortium for Medical Image Analysis, Sweden

Total Project Budget: 8 million EUR

Project Duration:  January 1, 2024 – December 31, 2029

The project is funded by Horizon Europe under grant agreement no. 101136812 (European partners) and UK Research and Innovation (UK partner). This project is part of the EU Cancer Mission.

Further information can be found at:


The Kick-Off-Meeting of the PREMIO COLLAB project took place in Copenhagen from January 31 to February 2, 2024.