Research Group MSMI
Research Group "Methods of Statistical Modeling in Medical Imaging"
The research group - founded in September 2008 within the Institute for Biomedical Image Analysis (IBIA) - is dealing with the development of statistical models of human anatomy and physiological processes. In this context the focus of the research group is twofold:
The first focus is the development, extension and application of algorihms and methods that allow the automatic creation of statistical models of shape and appearance in 2, 3 and 4 (time series) dimensions. This incorporates the following fields of (medical) image anaylsis:
Segmentation using statistical prior knowledge
Rigid and non-rigid registration
Statistical methods for dimensionality reduction
Statistical methods for classification and (nonlinear) regression
The second focus is the application of the developed statistical models of shape and appearance for diagnostic, therapeutic and interventional procedures. This covers especially the following topics:
Assessment of pathogenetic factors using 2, 3 or 4 (3D + time) dimensional images (e.g. x-ray,ultrasound, CT, MR, PET, SPECT)
Investigation of correspondences between specific diseases and specific properties (e.g. shape, inner structure, appearance) of an organ or organ part
Prediction of relevant parameters for diagnostis or therapy planning using medical image data of patients
Visualization of pathogenetic variations of shape and appearance among a population
The basis for this research is formed by the so called "InShape" models that have already been developed at the IBIA and were already successfully used for the segmentation of medical images (more). Moreover, InShape models were used for the automatic and objective placement of regions of interest (ROIs) and the assessment/prediction of pathogenetic factors and biomechanical paramters (more).
All developed algorithms and applications are implemented using C++. The open-source toolkits ITK and VTK form the basis for these implementations. By this means different image-processing and image-analysis modules have been developed at the IBIA.
In the following a brief overview of these modules will be given:
Image preprocessing module
This module provides an interface to selected (partly ITK) filters for image blurring, smoothing, thresholding, morphological operations, transformations, resampling,... in combination with 3 image viewers the are showing an image block in 3 orthogonal directions.
Screenshot of the image preprocessing module of the I-PRESP image processing and analysis framework.
Level set segmentation module
This module provides access to the ITK Level set toolbox. In particulary to the fast marching level seets, active geodesic level sets and threshold level set filter. In combination with basic manual 2D segmentation tools it provides functionalilty for interactive semi-automatic segmentation of 3D image data.
Demo video of a segementation of the left cardiac ventricle using fast marching and active geodesic level sets (flash player needed)
InShape model creation module
This module allows the automatic creation of 3D shape and appearance (InShape) models based on deformation fields created. In order to establish correspondences different combinations of rigid, affine and elastic registration (diffeomorphic demons, B-Spline registration) can be used. As input the user must provide image data and segmented binary labes of the organ that shall be modeled.
Model based segmentation module
With this module the created models can directly be used for segmentation. A combination of model based segmentation and level set segmentation is used for the automatic segmentation of 3D (+time) medical image data.
Proximal femur segmentation in CT image using 3D InShape model+level sets (left) and 3D segmentation result (right) (flash player needed)
3D endocardium segmentation using InShape model + level sets (flash player needed)
InShape model explorer module
Using this module the shape and appearance variations represented by different PCA modes can be visualized using different types of representations. Moreover, user-defined model instances can be created and saved for further processing.
Demo video shwoing the model explorer module (flash player needed)
This module provides tools for 3D surface rendering of binary data using marching cubes algorithm. The modeled scene can be edited by changing colors, lightning, type of surface representation, texturing,...
Screenshot of the 3D visualization module
2D/3D registration module XSePT
(X-ray "Segistration" Process Toolkit)
XSePT is a generic scientific tool for model-based 2D/3D image "segistration". It provides functionality for the (semi) automatic registration of either static 3D images (e.g. CT, MRI) or 3D InShape models on 2D images (e.g. x-ray). For this purpose digitally reconstructed radiographs (DRR) are computed using techniques like ray casting and wobbled splatting. XSePT was developed at the IBIA by DI Philipp Steininger
Screenshot of the 2D/3D "segistration" module
Demo video of 2D/3D hip registration using XSePT(flash player needed):
Karl D. Fritscher, MD, PhD
Head of the Research Group
Room: G3 41